Linogliride

**Semantic type:** Pharmacologic Substance

**Definition:** A guanidine-based insulin secratogogue and structural analogue of pirogliride with hypoglycemic activity. Linogliride blocks ATP-sensitive potassium channels on the membranes of pancreatic beta cells which stimulates the secretion of insulin and improves glucose tolerance. This agent is associated with CNS toxicity.

**Synonyms:** - LINOGLIRIDE - N-(1-Methyl-2-pyrrolidinylidene)-N'-phenyl-4-morpholinecarboxamidine