Mitoguazone

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. (NCI04)

**Synonyms:** - 1,1'-((methylethanediylidene)dinitrilo)diguanidine - 2,2'-(methyl-1,2-ethanediylidene)bis[hydrazinecarboximidamide] - DRG-0223 - MGBG - MITOGUAZONE - Me-GAG - Methyl GAG - Methyl GAG - Methyl-G - Methyl-GAG - Methylglyoxal Bisguanylhydrazone - Methylglyoxal bis(amidinohydrazone) - Zyrkamine - methylglyoxal bis(guanylhydrazone) - pyruvaldehyde bis(amidinohydrazone)