Phenprocoumon

**Semantic type:** Pharmacologic Substance

**Definition:** An orally available, long-acting derivative of coumarin with anticoagulant activity. Upon administration, phenprocoumon inhibits the vitamin K epoxide reductase enzyme; inhibition of this enzyme prevents the formation of the reduced, active form of vitamin K (vitamin KH2), which is essential for the carboxylation of glutamate residues of vitamin K-dependent proteins. This prevents the activation of vitamin K-dependent coagulation factors II, VII, IX, and X and the anticoagulant proteins C and S, which abrogates both thrombin production and thrombus formation.

**Synonyms:** - 2H-1-Benzopyran-2-one, 4-Hydroxy-3-(1-phenylpropyl)- - 3-(alpha-Phenylpropyl)-4-hydroxycoumarin - Liquamar - PHENPROCOUMON