Mitotane

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04)

**Synonyms:** - (o,p)-DDD - 1, 1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane - 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane - 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene - 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene - 2, 2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane - 2, 4'-Dichlorodiphenyldichloroethane - 2,2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane - 2,4'-Dichlorodiphenyldichloroethane - 2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane - CB 313 - CB-313 - Chloditan - Chloditan - Chlodithane - Chlodithane - DDD - Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro- - Khloditan - Lisodren - Lysodren - Lysodren - MITOTANE - Mytotan - Ortho,para-DDD - WR-13045 - mitotane - o,p' - DDD - o,p'-DDD - o,p'-DDD - o,p'-DDD