Mitoxantrone Hydrochloride

**Semantic type:** Antibiotic|Organic Chemical|Pharmacologic Substance

**Definition:** The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.

**Synonyms:** - 1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione Dihydrochloride - 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone Dihydrochloride - CL 232315 - DHAD - DHAD - DHAQ - DHAQ - Dihydroxyanthracenedione Dihydrochloride - MITOXANTRONE HYDROCHLORIDE - Mitoxantrone Dihydrochloride - Mitoxantroni Hydrochloridum - Mitozantrone Hydrochloride - Mitroxone - Neotalem - Novantrone - Novantrone - Onkotrone - Pralifan