Tolbutamide

**Semantic type:** Pharmacologic Substance

**Definition:** A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to cause adverse effects, such as jaundice. This agent is rapidly metabolized by CYPC29.

**Synonyms:** - N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide - TOLBUTAMIDE