Zofenoprilat Arginine

**Semantic type:** Pharmacologic Substance

**Definition:** The arginine salt of zofenoprilat, a sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Zofenoprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zofenoprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

**Synonyms:** - L-Proline, 1-(3-mercapto-2-methyl-1-oxopropyl)-4-(phenylthio)-, (1(R*),2alpha,4alpha)-, compd. with L-arginine (1:1) - SQ 26,703 - SQ 26703 - ZOFENOPRILAT ARGININE