Oblimersen Sodium

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** The sodium salt of a phosphorothioate antisense oligonucleotide targeted to the initiation codon region of mRNA for the anti-apoptotic gene Bcl-2. Oblimersen inhibits Bcl-2 mRNA translation, which may result in decreased expression of the Bcl-2 protein and tumor cell apoptosis. This agent may enhance the efficacy of standard cytotoxic chemotherapy. The anti-apoptotic bcl-2 protein is an integral outer mitochondrial membrane protein (OMMP) that is overexpressed in some cancer cell types and is linked to tumor drug resistance.

**Synonyms:** - Anticode G3139 - Augmerosen - BCL-2 Antisense Oligodeoxynucleotide G3139 - BCL-2 Antisense/G3139 - G 3139 - G-3139 - G3139 - G3139 Antisense Oligonucleotide - G3139 BCL-2 Antisense Oligo - G3139 BCL-2 Antisense Oligodeoxynucleotide - G3139 BCL-2 Antisense Oligonucleotide - Genasense - Genasense - OBLIMERSEN SODIUM - augmerosen - bcl-2 antisense oligodeoxynucleotide G3139 - oblimersen sodium