Selumetinib

**Semantic type:** Pharmacologic Substance

**Definition:** An orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers.

**Synonyms:** - ARRY-142886 - AZD 6244 - AZD-6244 - AZD6244 - AZD6244 - MEK Inhibitor AZD6244 - MEK inhibitor AZD6244 - SELUMETINIB