Dexrazoxane Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** The hydrochloride salt of a bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical-generating anthracycline-iron complexes, which may minimize anthracycline-iron complex-mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the catalytic activity of topoisomerase II, which may result in tumor cell growth inhibition.

**Synonyms:** - Cardioxane - DEXRAZOXANE HYDROCHLORIDE - Totect - Totect - Zinecard - Zinecard - dexrazoxane hydrochloride