Moxalactam

**Semantic type:** Antibiotic|Organic Chemical|Pharmacologic Substance

**Definition:** A semisynthetic oxa-beta-lactam antibiotic, with antibacterial activity used mainly against gram-negative aerobic bacteria. Replacing the beta-lactam sulfur atom for an oxygen atom and the presence of the methyltetrazolethio moiety and the para-hydroxyphenylmalonyl group, increases the antibacterial activity of moxalactam. The 7-alpha-methoxy group and the para-hydroxyphenylmalonyl group increases the stability of this agent against beta-lactamases. The use of this agent has been associated with fatal bleeding events.

**Synonyms:** - Latamoxef - Ly 127935 - MOXALACTAM - Moxam