Technetium Tc-99m Medronate

**Semantic type:** Pharmacologic Substance

**Definition:** A radiopharmaceutical containing methylene diphosphonate (medronate; MDP) complexed with the gamma-emitting radionuclide technetium Tc 99m with radioisotopic activity and hydroxyapatite affinity. Upon intravenous administration, skeletal uptake of technetium Tc 99m methylene diphosphonate occurs as a function of skeletal blood flow and osteogenic activity. The MDP moiety of this agent has affinity for hydroxyapatite crystals in bone with abnormal accumulation at sites with increased osteoid mineralization; labeling of MDP with Tc 99m allows scintigraphic imaging of areas of abnormal osteogenesis associated with malignant bone lesions.

**Synonyms:** - (99m)Tc-Medronate - 99mTc-MDP - TECHNETIUM TC-99M MEDRONATE - TechneScan MDP - Technetium Tc 99m Methylene Diphosphonate