NAT2*6 Allele

**Semantic type:** Gene or Genome

**Definition:** Human NAT2*6 allele is a designation for a group of variant alleles of the NAT2 gene, which is located in the vicinity of 8p22 and is approximately 10 kb in length. The wild-type allele, which encodes arylamine N-acetyltransferase 2 protein, is involved in the activation/deactivation of arylamine and hydrazine compounds. This group of allelic variants of the NAT2 gene all exhibit a SNP (c. 590G>A) that results in a R197Q coding change and may be associated with decreased enzymatic activity of the encoded protein.

**Synonyms:** - N-Acetyltransferase 2 (Arylamine N-Acetyltransferase)*6 Allele