FLT3 Internal Tandem Duplication

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A genetic abnormality that arises from duplications of the juxtamembrane portion of the gene and results in constitutive activation of the FLT3 receptor tyrosine kinase protein in early hematopoietic progenitor cells. It is associated with acute myelogenous leukemia where it appears to correlate with a poor prognosis.

**Synonyms:** - Activating FLT3-ITD Gene Mutation - Activating FLT3-ITD Mutation - FLT3 ITD - FLT3-ITD - FLT3-ITD Activating Mutation - FLT3-ITD Mutation - FLT3-ITD Mutation - FLT3/ITD Mutation