Naproxen

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Naproxen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of naproxen. Naproxen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.

**Synonyms:** - 6-Methoxy-alpha-methyl-2-naphthaleneacetic Acid - NAPROXEN - Naprosyn - Naprosyn - RS-3540 - d-2-(6-Methoxy-2-naphthyl)propionic Acid - naproxen