IKZF1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human IKZF1 wild-type allele is located within 7p13-p11.1 and is approximately 123 kb in length. This allele, which encodes DNA-binding protein Ikaros, plays a role in transcriptional enhancement. Truncated and mutated forms of the gene can be a factor in acute lymphoblastic leukemia. A translocation t(3;7)(q27;p12) that fuses the gene to the BCL6 gene is implicated in diffuse large B-cell lymphomas.

**Synonyms:** - CVID13 - Hs.54452 - IK1 - IKAROS - IKAROS Family Zinc Finger 1 (Ikaros) Gene - IKAROS Family Zinc Finger 1 wt Allele - IKZF1 - LYF1 - LyF-1 - PPP1R92 - PRO0758 - Protein Phosphatase 1, Regulatory Subunit 92 Gene - ZNFN1A1 - Zinc Finger Protein, Subfamily 1A, 1 (Ikaros) Gene - Zinc Finger Protein, Subfamily 1A, Member 1 Gene - hIk-1