Abiraterone Acetate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally active acetate ester form of the steroidal compound abiraterone with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels.

**Synonyms:** - 17-(3-Pyridyl)-5,16-androstadien-3beta-acetate - ABIRATERONE ACETATE - Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, acetate (ester), (3beta)- - BR9004 - BR9004-1 - CB 7630 - CB-7630 - CB7630 - JNJ-212082 - Yonsa - Zytiga - abiraterone acetate