Cetoquagene Parvec

**Semantic type:** Pharmacologic Substance

**Definition:** A replication-deficient, recombinant adenovirus encoding human aquaporin-1 with potential membrane water channel activity. Upon transfection of salivary glands, cetoquagene parvec directs human aquaporin-1 (hAQP1) expression in the apical and basolateral plasma membranes of salivary secretory cells, which may result in increased saliva production. hAQP1, a water channel protein, is one of several highly conserved water channel proteins that mediate water permeability in cells of water-transporting tissues.

**Synonyms:** - AAV2 hAQP1 - AAV2-hAQP1 - AAV2hAQP1 - Adenovirus Encoding Human Aquaporin-1 - AdhAQP1 - CETOQUAGENE PARVEC