Fostamatinib Disodium

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.

**Synonyms:** - 2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]- 4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-, Disodium Salt, Hexahydrate - FOSTAMATINIB DISODIUM - Fostamatinib Disodium Hexahydrate - R-935788 Sodium - R788 Sodium - R788 sodium - R935788 Sodium - SYK Kinase Inhibitor R-935788 - Syk kinase inhibitor R-935788 - Tavalisse