Hand-Schuller-Christian Disease

**Semantic type:** Neoplastic Process

**Definition:** A multifocal, unisystem form of Langerhans-cell histiocytosis. There is involvement of multiple sites in one organ system, most frequently the bone. Patients are usually young children presenting with multiple destructive bone lesions.

**Synonyms:** - Classic Multifocal Langerhans Cell Histiocytosis - Hand-Schuller-Christian disease - Hand-Schüller-Christian Disease - Multifocal Unisystem Langerhans Cell Histiocytosis - Multifocal and unisystemic Langerhans-cell histiocytosis