Langerhans Cell Sarcoma

**Semantic type:** Neoplastic Process

**Definition:** A neoplastic proliferation of Langerhans cells with overtly malignant cytologic features. It can be considered a higher grade variant of Langerhans cell histiocytosis (LCH) and it can present de novo or progress from antecedent LCH. (WHO, 2001)

**Synonyms:** - Langerhans cell sarcoma