Germinoma

**Semantic type:** Neoplastic Process

**Definition:** A malignant germ cell tumor arising from the central nervous system. It is composed of uniform cells resembling primitive germ cells. These cells have large, vesicular nuclei, prominent nucleoli and a clear, glycogen-rich cytoplasm. Additional features are lymphoid or lymphoplasmacytic infiltrates and, less frequently, scattered syncytiotrophoblastic giant cells. (Adapted from WHO)

**Synonyms:** - Central Nervous System Germinoma - Germinoma of CNS - Germinoma of CNS - Germinoma of Central Nervous System - Germinoma of the CNS - Germinoma of the Central Nervous System