Ramucirumab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A recombinant, fully human monoclonal antibody directed against human vascular endothelial growth factor receptor 2 (VEGFR-2) with antiangiogenesis activity. Ramucirumab specifically binds to and inhibits VEGFR-2, which may result in an inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR-2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells.

**Synonyms:** - Anti-VEGFR-2 Fully Human Monoclonal Antibody IMC-1121B - Cyramza - IMC 1121B - IMC-1121B - IMC-1121B - IMC1121B - LY 3009806 - LY-3009806 - LY3009806 - Monoclonal Antibody HGS-ETR2 - RAMUCIRUMAB - anti-VEGFR-2 fully human monoclonal antibody IMC-1121B - ramucirumab