HNF1B wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human HNF1B wild-type allele is located within 17cen-q21.3 and is approximately 59 kb in length. This allele, which encodes hepatocyte nuclear factor 1-beta protein, plays a role in the modulation of transcription in hepatocytes. Mutations that add a premature stop codon to the gene are a factor in the occurrence of maturity-onset of diabetes, type 5.

**Synonyms:** - FJHN - HNF-1B - HNF1 Homeobox B wt Allele - HNF1beta - HNF2 - HPC11 - Hepatocyte Nuclear Factor 1 Beta Gene - Hepatocyte Nuclear Factor 2 Gene - LF-B3 - LFB3 - MODY5 - TCF-2 - TCF2 - Transcription Factor 2, Hepatic Gene - Transcription Factor, Liver-Specific Gene - VHNF1 - Variant Hepatic Nuclear Factor Gene