Tamibarotene

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. As a specific retinoic acid receptor (RAR) alpha/beta agonist, tamibarotene is approximately ten times more potent than ATRA in inducing cell differentiation and apoptosis in HL-60 (human promyelocytic leukemia) cell lines in vitro. Due to a lower affinity for cellular retinoic acid binding protein (CRABP), tamibarotene may show sustained plasma levels compared to ATRA. In addition, this agent may exhibit a lower toxicity profile than ATRA, in part, due to the lack of affinity for the RAR-gamma receptor, the major retinoic acid receptor in the dermal epithelium.

**Synonyms:** - 4-((5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl) - Am-80 - Am80 - Benzoic Acid, 4-(((5,6,7,8-tetrahydro-5,5,8,8-Tetramethyl-2-naphthalenyl)amino)carbonyl)- - INNO-507 - N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)terephthalamic Acid - Retinobenzoic Acid - SY-1425 - TAMIBAROTENE - TM-411 - TOS-80T - Z-208