HLA-DRB4 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human HLA-DRB4 wild-type allele is located in the vicinity of 6p21.3 and is approximately 15 kb in length. This allele, which encodes HLA class II histocompatibility antigen, DRB4 beta chain protein, plays a role in the regulation of antigen presentation. The gene is polymorphic and typing is often performed to determine histocompatibility for hematopoietic stem cell transplantation.

**Synonyms:** - DR4 - DRB4 - HLA-DR4B - HLA-DRB4* - Human Leucocyte Antigen DRB4 - Human Leukocyte Antigen DRB4 - Major Histocompatibility Complex, Class II, DR Beta 4 wt Allele