PRNP wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PRNP wild-type allele is located in the vicinity of 20p13 and is approximately 15 kb in length. This allele, which encodes major prion protein, plays a role in both the extracellular surface and the development of prion diseases. Mutations in the gene are associated with inherited transmissible spongiform encephalopathies.

**Synonyms:** - ASCR - CD230 - CJD - GSS - MGC26679 - PRIP - PrP - PrP27-30 - PrP33-35C - PrPc - Prion Protein (p27-30) (Creutzfeldt-Jakob Disease, Gerstmann-Strausler-Scheinker Syndrome, Fatal Familial Insomnia) wt Allele