Major Prion Protein

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** Major prion protein (253 aa, ~28 kDa) is encoded by the human PRNP gene. This protein is bound to the membrane by a glycosylphosphatidylinositol-anchor and it plays a role in the pathology and transmission of human prion diseases.

**Synonyms:** - ASCR - CD230 antigen - PRNP - PrP - PrP27-30 - PrP33-35C