Indoximod

**Semantic type:** Pharmacologic Substance

**Definition:** A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.

**Synonyms:** - 1-MT - 1-Methyl-D-tryptophan - 1-methyl-d-tryptophan - D-(+)-1-Methyltryptophan - D-1MT - INDOXIMOD