Inotuzumab Ozogamicin

**Semantic type:** Immunologic Factor|Pharmacologic Substance

**Definition:** A CD22-targeted cytotoxic immunoconjugate composed of a humanized IgG4 anti-CD22 antibody covalently linked to N-acetyl-gamma-calicheamicin dimethyl hydrazide (CalichDMH) with potential antineoplastic activity. Inotuzumab ozogamicin is rapidly internalized upon binding of the antibody moiety to B cell-specific CD22 receptors, delivering the conjugated CalichDMH intracellularly; the CalichDMH moiety binds to the minor groove of DNA in a sequence-specific manner, resulting in double-strand DNA breaks and apoptosis. CalichDMH is a derivative of gamma calicheamicin, a cytotoxic antibiotic produced by the bacterium Micromonospora echinospora.

**Synonyms:** - Besponsa - CMC 544 - CMC-544 - CMC544 - INOTUZUMAB OZOGAMICIN - Inotuzumab ozogamicin - WAY-207294 - Way 207294