Dendritic Cell-Idiotype-Keyhole Limpet Hemocyanin Vaccine

**Semantic type:** Immunologic Factor|Pharmacologic Substance

**Definition:** A cell-based vaccine composed of allogeneic dendritic cells (DC), pulsed with patient-specific non-Hodgkin's lymphoma idiotype (Id) determinants conjugated to keyhole limpet hemocyanin (KLH), with potential antitumor activity. Upon administration, this vaccine may stimulate the host immune system to mount a specific cytotoxic T-lymphocyte (CTL) response against Id-expressing lymphoma cells, resulting in tumor cell lysis.

**Synonyms:** - DC-Id-KLH Vaccine