Methotrexate-Associated Lymphoproliferative Disorder

**Semantic type:** Neoplastic Process

**Definition:** A lymphoproliferative disorder that develops in patients who are immunosuppressed with methotrexate. This disorder is often Epstein-Barr virus positive, and morphologically it may resemble large B-cell non-Hodgkin lymphoma, Hodgkin lymphoma, or a polymorphous post-transplant lymphoproliferative disorder. (WHO, 2001)

**Synonyms:** - Methotrexate-Related Lymphoproliferation - Methotrexate-Related Lymphoproliferative Disorder