Alfaxalone

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic neuroactive steroid, with anesthetic activity. Upon administration, alfaxalone binds to the gamma-aminobutyric acid (GABA)-A cell surface receptor, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to modulation of neuronal cell membrane chloride ion transport and induction and maintenance of anesthesia.

**Synonyms:** - ALFAXALONE - Alfaxan - Alphaxalone - Alphaxolone