Pomalidomide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally bioavailable derivative of thalidomide with potential immunomodulating, antiangiogenic and antineoplastic activities. Although its exact mechanism of action has yet to be fully elucidated, pomalidomide appears to inhibit TNF-alpha production, enhance the activity of T cells and natural killer (NK) cells and enhance antibody-dependent cellular cytotoxicity (ADCC). In addition, pomalidomide may inhibit tumor angiogenesis, promote cell cycle arrest in susceptible tumor cell populations, and stimulate erythropoeisis.

**Synonyms:** - 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide - 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione - 4-Aminothalidomide - Actimid - CC 4047 - CC-4047 - CC-4047 - CC4047 - Imnovid - POMALIDOMIDE - Pomalyst - pomalidomide