UGT1A1*28 Allele

**Semantic type:** Gene or Genome

**Definition:** Human UGT1A1*28 allele is located in the vicinity of 2q37 and is approximately 13 kb in length. This allele, which encodes UDP-glucuronosyltransferase 1-1 protein, plays a role in the transformation of small lipophilic molecules into water-soluble metabolites. UGT1A1*28 allele has a polymorphism in the promoter region that is associated with decreased transferase activity and decreases in both tolerance and effectiveness of cancer therapeutics and antiviral drugs.

**Synonyms:** - NM_000463.2:c.-55_-54dupAT - NM_000463.2:c.-55_-54insAT - UDP Glucuronosyltransferase Family 1 Member A1*28 Allele - UDP Glycosyltransferase 1 Family, Polypeptide A1*28 Allele - UGT1A1 (TA)7 Allele - UGT1A1 A(TA)7TAA Allele - UGT1A1 NM_000463.2:c.-55_-54dupAT - UGT1A1 NM_000463.2:c.-55_-54insAT - UGT1A1 TATA Element ins TA Allele - UGT1A1 Variant (TA)7 Allele - UGT1A1 Variant Allele (TA)7 - UGT1A1 c.-55_-54dupAT - UGT1A1 c.-55_-54insAT - UGT1A1*28 - UGT1A1, 2-BP ins, TA, TATAA Element Allele