Fosaprepitant Dimeglumine

**Semantic type:** Pharmacologic Substance

**Definition:** The dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent binds selectively to the human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS). This inhibits receptor binding of the endogenous substance P and prevents substance P-induced emesis.

**Synonyms:** - Emend for Injection - FOSAPREPITANT DIMEGLUMINE - Focinvez - L-785,298 - MK-0517 - Proemend - fosaprepitant dimeglumine