Darapladib

**Semantic type:** Pharmacologic Substance

**Definition:** A substituted pyrimidone with inhibitory activity towards lipoprotein-associated phospholipase-A2 (Lp-PLA2), an important regulator of lipid metabolism and inflammation that circulates with lipoprotein particles and is carried into the arterial wall with low-density lipoprotein particles during the progression of atherosclerosis.

**Synonyms:** - DARAPLADIB - GSK480848 - SB 480848