Amitivir

**Semantic type:** Pharmacologic Substance

**Definition:** An inhibitor of inosine monophosphate dehydrogenase with activity against several influenza A and B viruses. Amitivir inhibits the conversion of inosine monophosphate to xanthosine monophosphate, the rate-limiting step in the de novo biosynthesis of guanine nucleotides, leading to inhibition of cell proliferation.

**Synonyms:** - 1,3,4-Thiadiazole-2-carbamonitrile - AMITIVIR - Cyanamide, 1,3,4-thiadiazol-2-yl- - LY 217896