Buciclovir

**Semantic type:** Pharmacologic Substance

**Definition:** An acyclic guanosine analog with activity against herpes simplex virus (HSV). Buciclovir is phosphorylated to its triphosphate form by HSV thymidine kinase in infected cells and acts as a specific inhibitor of the viral DNA polymerase. It is incorporated into both RNA and DNA but only inhibits DNA synthesis.

**Synonyms:** - (R)-9-(3,4-Dihydroxybutyl)guanine - 2-Amino-9-(R)-3,4-dihydroxybutyl-9H-purin-6(1H)-on - BCV - BUCICLOVIR