Histone-Lysine N-Methyltransferase SUV39H1

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Histone-lysine N-methyltransferase SUV39H1 (412 aa, ~48 kDa) is encoded by the human SUV39H1 gene. This soluble, nuclear protein plays a role in establishment of constitutive heterochromatin at pericentric and telomeric regions. Trimethylation of H3K9 is also required to direct DNA methylation at pericentric repeats.

**Synonyms:** - EC 2.1.1.43 - H3-K9-HMTase 1 - Lysine N-methyltransferase 1A - Position-effect variegation 3-9 homolog - Su(var)3-9 homolog 1 - Suppressor of variegation 3-9 homolog 1 - Suv3-9h1