Histone-Lysine N-Methyltransferase H3 Lysine-79 Specific

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Histone-lysine N-methyltransferase, H3 lysine-79 specific (1379 aa, ~185 kDa) is encoded by the human DOT1L gene. This soluble, nuclear protein may play a role in activating or repressing transcription by RNA polymerase II.

**Synonyms:** - DOT1-Like Protein - DOT1L - EC 2.1.1.43 - H3-K79-HMTase - Histone H3 Methyltransferase DOT1-Like - Histone H3-K79 Methyltransferase - Histone Methyltransferase DOT1L - K79 Methyltransferase - Lysine N-Methyltransferase 4