Fluciclovine F18

**Semantic type:** Indicator, Reagent, or Diagnostic Aid|Pharmacologic Substance

**Definition:** A radiotracer containing a synthetic amino acid analogue of L-leucine radiolabeled with fluorine F 18 with potential diagnostic imaging use. Similar to most amino acids, fluciclovine F18 appears to enter cells through the energy-independent L-type amino acid transporter (LAT) system. As an amino acid analogue, this agent is preferentially accumulated by tumor cells due to their increased metabolic needs; however, unlike naturally occurring amino acids, this non-natural amino acid-analogue radiotracer is not metabolized. Accordingly, fluciclovine F18 accumulates in tumor cells and can potentially be used to image tumors using positron emission tomography (PET).

**Synonyms:** - (18F)Fluciclovine - (18F)GE-148 - (1R,3R)-1-Amino-3(18f)fluorocyclobutane-1-carboxylic Acid - 18F-Fluciclovine - Anti-(18f)FABC - Anti-1-Amino-3-[18F]Fluorocyclobutane-1-Carboxylic Acid - Anti-[18F] FACBC - Axumin - Axumin - FLUCICLOVINE F-18 - Fluciclovine (18F) - GE-148 (18F) - GE-148 F-18 - [18F]FACBC