Hairy Cell Leukemia Variant

**Semantic type:** Neoplastic Process

**Definition:** An indolent chronic B-cell leukemia resembling classic hairy cell leukemia but shows variant cytologic, hematologic, and immunophenotypic features and is resistant to the conventional therapy applied to hairy cell leukemia. Biologically, it is not related to hairy cell leukemia.

**Synonyms:** - HCL-V - Hairy Cell Leukemia-Variant - Hairy cell leukemia variant - Prolymphocytic Variant of Hairy Cell Leukemia - SBLPN - Splenic B-Cell Lymphoma/Leukemia with Prominent Nucleoli