Apricoxib

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. COX-related metabolic pathways may represent crucial regulators of cellular proliferation and angiogenesis.

**Synonyms:** - APRICOXIB - COX-2 Inhibitor TG01 - CS-706 - R-109339 - TG01 - TP2001