Indium In 111 Monoclonal Antibody HuPAM4

**Semantic type:** Amino Acid, Peptide, or Protein|Indicator, Reagent, or Diagnostic Aid|Pharmacologic Substance

**Definition:** The humanized monoclonal antibody huPAM4, directed against the pancreatic cancer antigen MUC-1 and labeled with the gamma-emitting radioisotope indium In 111, with radioisotopic and antibody activities. Upon administration, indium In 111 monoclonal antibody huPAM4 may bind to MUC-1-positive tumor cells, allowing radioimmunolocalization with gamma scintigraphy. Overexpressed by many tumor cell types, MUC-1 antigen, a mammary-type apomucin, is a high-molecular-weight transmembrane glycoprotein.

**Synonyms:** - 111 In- Labeled Humanized PAM4 IgG - In-111-HuPAM4