Sirolimus Albumin-bound Nanoparticles

**Semantic type:** Pharmacologic Substance

**Definition:** The macrolide antibiotic rapamycin bound to nanoparticle albumin with immunosuppressant (see sirolimus) and potential antiangiogenic and antineoplastic activities. Rapamycin binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate a complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. In turn, inhibition of mTOR may result in the inhibition of the phosphatidylinositol 3 (PI-3) kinase/Akt pathway and vascular endothelial cell growth factor (VEGF) secretion, which may result in decreased tumor cell proliferation and tumor angiogenesis. The binding of water-insoluble rapamycin to nanoparticle albumin permits the albumin-mediated endocytosis of rapamycin by tumor cells and endothelial cells.

**Synonyms:** - ABI 009 - ABI-009 - ABI009 - Albumin-bound Sirolimus - Fyarro - Nab-Rapamycin - Nab-sirolimus - Nanoparticle Albumin-Bound Rapamycin - Nanoparticle Albumin-bound Sirolimus - Sirolimus Albumin-bound Particles - Sirolimus Protein-bound Particles - Sirolimus protein-bound particles