NOD2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human NOD2 wild-type allele is located in the vicinity of 16q21 and is approximately 36 kb in length. This allele, which encodes nucleotide-binding oligomerization domain-containing protein 2, plays a role in the modulation of both cell death and immune response. Mutation of the gene is associated with Blau syndrome, Crohn disease, ulcerative colitis, and early-onset sarcoidosis.

**Synonyms:** - ACUG - BLAU - CARD15 - CD - CLR16.3 - IBD1 - NLRC2 - NOD2B - Nucleotide-Binding Oligomerization Domain Containing 2 wt Allele - PSORAS1