Vatalanib Succinate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The succinate salt of vatalanib, an anilinophthalazine derivative, with antineoplastic activity. Vatalanib binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2; both receptor tyrosine kinases are involved in angiogenesis. This agent also binds to and inhibits related receptor tyrosine kinases, including platelet-derived growth factor (PDGF) receptor, c-Kit, and c-Fms.

**Synonyms:** - 1-[4-Chloroanilino]-4-[4-pyridylmethyl]phthalazine Succinate - Butanedioic Acid, Compd. with N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine (1:1) - CGP 79787D - PTK 787 - PTK-787 - PTK787 - VATALANIB SUCCINATE - ZK 222584