SH2D1A wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human SH2D1A wild-type allele is located within Xq25-q26 and is approximately 27 kb in length. This allele, which encodes SH2 domain protein 1A, plays role in activation, proliferation and differentiation of B and T cells, induces production of IFN gamma, and changes the functional profile of subsets of T cells. Mutations in this gene are associated with X-linked lymphoproliferative syndrome 1 (Duncan Disease).

**Synonyms:** - DSHP - EBVS - FLJ18687 - FLJ92177 - IMD5 - LYP - MTCP1 - RP5-1052M9.3 - SAP - SAP/SH2D1A - SH2 Domain Containing 1A wt Allele - SH2 Domain Protein 1A, Duncan's Disease (Lymphoproliferative Syndrome) Gene - XLP - XLPD - XLPD1