Smith-Magenis Syndrome

**Semantic type:** Disease or Syndrome

**Definition:** A genetic syndrome caused by an interstitial deletion in chromosome 17p11.2. It is characterized by mild to moderate mental retardation, distinctive facial features (flat head, square face, and deep set-eyes), sleep disturbances, attention deficit disorders, and temper tantrums.

**Synonyms:** - Chromosome 17p11.2 Deletion Syndrome